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KMID : 0981820090290050379
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Korean Journal of Laboratory Medicine
2009 Volume.29 No. 5 p.379 ~ p.383
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Detection of PML/RARA Rearrangement by Reverse Transcriptase-PCR and Sequencing in a Case of Microgranular Acute Promyelocytic Leukemia Lacking t(15;17) on Karyotype and FISH
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Kim Kyong-Eun
Woo Kwang-Sook
Kim Sung-Hyun
Han Jin-Yeong
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Abstract
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We report a case of morphologically microgranular acute promyelocytic leukemia with PML/RARA fusion transcripts demonstrated by reverse transcriptase-PCR and cDNA sequencing, and no PML/RARA fusion detected by karyotype and FISH analyses. Karyotype was 47,XX,+8[19]/46,XX[1]. Although the newer FISH probes provide more accurate detections of t(15;17), it would be necessary to perform other molecular tests to further identify the masked PML/RARA fusions.
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KEYWORD
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Cryptic PML/RARA rearrangement, Acute promyelocytic leukemia, RT-PCR, PML/RARA, Trisomy 8
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